Correlation between Cytomegalovirus (CMV) Infection in Children with Cerebral Palsy (CP) and Future Anxiety among Parents

Isti Anindya, Nur Eni Lestari


One of the causes of Cerebral Palsy (CP) is a viral infection in the mother during pregnancy. The most recorded infections were Cytomegalovirus (CMV) infections. Inappropriate parenting can affect the psychological condition of CP children. Psychological conditions that are not good can cause the child's immune system to decrease and increase the risk of CMV reactivation. This is one factor in the emergence of parental anxiety about the future sustainability of their CP children. It was to determine the relationship of anti-cytomegalovirus (CMV) Immunoglobulin G in children with CP with future anxiety among parents. The design of this study used a cross-sectional approach that using CP children and their parents. Serological examination used the ELFA (Enzyme-Linked Fluorescent Assay) method for 40 CP children and a questionnaire on the future anxiety of parents of children with special needs were answered directly by the parents of CP children, 40 fathers and 40 mothers. Analysis of the research data used Spearman Rank. The results of this study found an anti-CMV IgG seropositive relationship in CP children with future anxiety in fathers (p-value = 0.022; a< 0.05) and mothers (p-value = 0.011; a< 0.05). If anxiety in parents has not good treatment, it will impact the care of CP children, the developmental progress of CP children will not optimal.


Cytomegalovirus; Cerebral Palsy; IgG; Future Anxiety

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Altayeb, M. A., Mokhtar, S. I., Adam, M. E., Mohammed, S. I., & Musa, H. H. (2016). Detection of primary CMV infection in Sudanese pregnant women by IgG avidity test. Asian Pacific Journal of Tropical Disease, 6(10), 816–818.

Barreto, T. M., Bento, M. N., Barreto, T. M., Jagersbacher, J. G., Jones, N. S., Lucena, R., &

Bandeira, I. D. (2019). Prevalence of depression, anxiety, and substance-related disorders in parents of children with cerebral palsy: A systematic review. Developmental Medicine & Child Neurology, (1), 1–6.

Bujnowska, A. M., Rodríguez, C., García, T., Areces, D., & Marsh, N. V. (2019). Parenting and future anxiety: The impact of having a child with developmental disabilities. International Journal of Environmental Research and Public Health, 16, 668–16.

Cameron, N. A., Gormley, M. E., & Deshpande, S. (2013). Severity of disability in patients with cerebral palsy secondary to symptomatic congenital cytomegalovirus encephalopathy. Journal of Pediatric Rehabilitation Medicine, 6, 241–244.

Cheshire, A., Barlow, J. H., & Powell, L. A. (2010). The psychosocial well-being of parents of children with cerebral palsy: A comparison study. Disability and Rehabilitation, 32(20), 1673–1677.

Guillamon, N., Nieto, R., Pousada, M., Redolar, D., Munoz, E., Hernandez, E., … Gomez-Zuniga, B. (2013). Quality of life and mental health among parents of children with cerebral palsy:Tthe influence of self-efficacy and coping strategies. Journal of Clinical Nursing, 22, 1579–1590.

Kamel, N., Metwally, L., Gomaa, N., Ahmed, W. A. S., Lotfi, M., & Younis, S. (2014). Primary cytomegalovirus Infection in pregnant egyptian eomen confirmed by cytomegalovirus IgG avidity testing. Medical Principles and Practice, 23, 29–33.

Lazzarotto, T., Blázquez-gamero, D., Delforge, M., & Foulon, I. (2020). Congenital cytomegalovirus infection: A narrative review of the issues in screening and management from a panel of European Experts. Journal Frontiers in Pediatrics, 8(13), 1–8.

Miloyan, B., Pachana, N. A., & Suddendorf, T. (2017). Future-Oriented thought patterns associated with anxiety and depression in later life: The intriguing prospects of prospection. The Gerontologist, 57(4), 619–625.

Prince, H. E., & Lapé-nixon, M. (2014). Role of Cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clinical and Vaccine Immunology, 21(10), 1377–1384.

Rector, J. L., Dowd, J. B., Loerbroks, A., Burns, V. E., Moss, P. A., Jarczok, M. N., … Bosch, J. A. (2014). Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample. Brain Behavior and Immunity, 38, 133–141.

Ribeiro, M. F. M., Sousa, A. L. L., Vandenberghe, L., & Porto, C. C. (2014). Parental stress in mothers of children and adolescents with cerebral palsy. Rev. Latino-Am. Enfermagem, 22(3), 440–447.

Ross, S. A., Novak, Z., Pati, S., & Boppana, S. B. (2011). Diagnosis of cytomegalovirus infections. Infectious Disorders Drug Targets, 11(5), 466–474.

Schleiss, M. R. (2018). Congenital cytomegalovirus: Impact on child health. Contemporary Pediatrics, 35(7), 16–24.

Smithers-sheedy, H., Raynes-greenow, C., & Badawi, N. (2014). Congenital cytomegalovirus is associated with severe forms of cerebral palsy and female sex in a retrospective population-based study. Developmental Medicine & Child Neurology, 56(9), 846–852.

Smithers-sheedy, H., Raynes-greenow, C., Badawi, N., Fernandez, M. A., Kesson, A., Mcintyre, S., … Jones, C. A. (2017). Congenital cytomegalovirus among children with cerebral palsy. The Journal of Pediatrics, 181, 267–271.

Türkoğlu, S., Bılgıç, A., Türkoğlu, G., & Yilmaz, S. (2016). Impact of symptoms of maternal anxiety and depression on quality of life of children with cerebral palsy. Noropsikiyatri Arsivi, 53(1), 46–51.

Wang, Y., Huang, Z., & Kong, F. (2020). Parenting stress and life satisfaction in mothers of children with cerebral palsy: The mediating effect of social support. Journal of Health Psychology, 25(3), 416–425.



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