Hypocholesterolemic Activity of Kedawung (Parkia roxburghii)

Nurul Isnaini Fitriyana, Kosuke Nishi, Takuya Sugahara


The purpose of this study is to investigate the hypocholesterolemic activity of kedawung (Parkia roxburghii), an underutilized and lesss-known tree nut. Kedawung was prepared into kedawung powder (BK), kedawung extract (SK) and hydrolyzed kedawung (HK) and then analyzed for its proximate and total phenol content. Furthermore, SK and HK were administered to rats to evaluate their effects on the lipid profile. Oral administration of HK at 160 mg/kg body weight increased the HDL cholesterol level and lowered the LDL and total cholesterol levels in blood of the administered rats. Among groups of the administered rats that completed the 35-day treatment, total cholesterol and LDL cholesterol were significantly reduced (p<0.01). The present data showed that kedawung has a hypocholesterolemic activity because of its phenolic content that acts as antioxidant that can bind cholesterol in blood; composition and distribution of amino acid in HK that changed the cholesterol metabolism (reduced cholesterol concentration); protein content in HK that increased the production of lipoprotein that plays a role in suppression of plaque and atherosclerosis. Therefore, hydrolyzed kedawung can be used as an hypocholesterolemic food material.


Kedawung; Hypocholesterolemic;

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Adams, M.R., Golden, D., Franke, A.A., and Anthony, M.S. (2004). Dietary soy-conglycicin (7S globulin) inhibits atherosceloris in mice. The Journal of Nutrition, 134(3), 511-516.

Angami, T., Bhagawati, R., Touthang, L., Makdoh, B., Nirmal, Lungmuana, Bharati, K.A., Silambarasan, R., and Ayyanar, M. (2018). Traditional uses, phytochemistry, and biological activities of Parkia timoriana (DC.) Merr., an underutilized multipurpose tree bean: a review. Genetic Resource and Crop Evolution, 65(2018), 679-692.

Blainski, A., Lopes, G.C., and Palazza de Mello, J.C. (2013). Application and analysis of the Folin-Ciocalteu method for the determination of the total phenolic content from Limonium brasiliense L. Molecules 18(6), 6852-6865.

Dajanta, K., Chukeatirote, E., and Apichartsrangkoon, A. (2011). Analysis and characterisation of amino acid contents of thua nao, a traditionally fermented soybean food of Northern Thailand. International Food Research Journal, 18 (2), 595-599.

Fatimah, S., Aliman, H., and Daud, N. (2018). The effect of seaweed extract (Sargassum sp) used as fertilizer on plant growth of Capsicum annum (chili) and Lycopersicon esculentum (tomato). Indonesian Journal of Science and Technology, 3(2), 115-123.

Fatimah, S., Aliman, H., and Daud, N. (2019). Phytochemical screening of Sargassum sp and in vitro seed germination test. Indonesian Journal of Science and Technology, 4(1), 48-54.

Fitriyana, N.I. (2017). Potensi pangan fungsional berbasis edamame sebagai pangan antikolesterol. Rekapangan Jurnal Teknologi Pangan, 11(1), 10-19.

Gibbs, B.F., Zougman, A., Masse, R., and Mulligan, C. (2004). Production and characterization of bioactive peptide from soy hidrolysate and soy-fermented food. Food Research International, 37(2), 123-131.

Longvah, T. and Deosthale, Y.G. (1997). Nutrient composition and food potential of Parkia roxburghii, a less known tree nut from northeast India. Food Chemistry, 62(4), 471-481.

Masuda, K., Jue, T., and Hamidie, R.D.R. (2017). Mitochondrial biogenesis induced by exercise and nutrients:implication for performance and health benefits. Indonesian Journal of Science and Technology, 2(2), 221-229.

Mateos-Aparicio, I., Cuenca, A.R., Villanueva-Suarez, M.J., and Zapata-Revilla, M.A. (2008). Soybean, a promising health source. Nutrition Hospitalaria, 23(4), 305-312.

Mourad, A.M., Pincinato, E., Sabha, M., and Moriel, P. (2009). Influence of soy lecithin administration on hypercholesterolemia. Cholesterol, 2010(1), 813-824.

Ponnusha, B.S., Pasupathi, P., Subramaniyam, B., Sathiyamoorthy, Subramaniyam, and Virumandy, R. (2011). A complete evaluation of the antioxidant and antimicrobial potential of Glycine max L. International Journal of Current Scientific Research, 1(2), 06-12.

Salam, J.S., Salam, P., Potshangbam, K.S., and Kumar, D.B. (2014). Effect of processing methods on secondary metabolites and enzyme inhibitors an different stages of Parkia roxburghii G. Dons pods. American Journal of Food Technology, 9(2), 89-96.

Samruan, W., Oonsivilai, R., and Oonsivilai, A. (2012.) Soybean and fermented soybean extract antioxidant activites. International Journal of Nutrition and Food Engineering, 6(12), 1134-1137.

Sathya, A. and Siddhuraju, P. (2015) Effect of processing method on compositional evaluation of underutilized legume, Parkia roxburghii G. Don (yongchak seed). Journal of Food Science Technology, 52(10), 6157-6169.

Yoshie-Stark, Y., and Wasche, A. (2004). In vitro binding of bile acids by Lupin isolates and their hydrolysates. Journal of Food Chemistry, 88(2004), 179-184.

Yoshikawa, M., Fujita, H., Matoba, N., Takenaka, Y., Yamamoto, T., Yamauchi, R., Tsuruki, H., and Takahata, K. (2005) Bioactive peptides derived from food proteins preventing lifestyle-related diseases. in:a new frontier in soy bioactive peptides that may prevent age related chronic diseases. Comprehensive Review in Food Science and Food Safety, 4(2005), 63-78.

Zhong, F., Liu, J., Ma, J., and Shoemaker, C.F. (2007). Preparation of hypocholesterol peptides from soy protein and their hypocholesterolemic effect in mice. Food Research International, 40(6), 661-667.

DOI: https://doi.org/10.17509/ijost.v6i2.34544


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